COVID-19 pill developers aim to top Merck, Pfizer efforts
As Merck & Co and Pfizer Inc prepare to report clinical-trial results for experimental Covid-19 antiviral pills, rivals are lining up with what they hope will prove to be more potent and convenient oral treatments of their own, Reuters reports.
Enanta Pharmaceuticals, Pardes Biosciences, Japan's Shionogi & Co Ltd and Novartis AG said they have designed antivirals that specifically target the coronavirus while aiming to avoid potential shortcomings such as the need for multiple pills per day, or known safety issues.
Infectious disease experts stressed that preventing Covid-19 through wide use of vaccines remains the best way to control the pandemic. But they said the disease is here to stay and more convenient treatments are needed.
"We need to have oral alternatives for suppression of this virus. We have people who aren't vaccinated getting sick, people whose vaccine protection is waning, and people who can't get vaccinated," said Dr Robert Schooley, an infectious diseases professor at University of California San Diego School of Medicine.
Pfizer and Merck, as well as partners Atea Pharmaceuticals and Roche, have all said they could seek emergency approval for their Covid-19 antiviral pills this year.
Rivals are at least a year behind. Pardes began an early-stage trial last month, Shionogi plans to start large-scale clinical trials by year-end, Enanta aims to start human trials early next year, and Novartis is still testing its pill in animals.
Antivirals are complex to develop because they must target the virus after it is already replicating inside human cells without damaging healthy cells. They also need to be given early to be most effective.
Currently, intravenous and injected antibodies are the only approved treatments for non-hospitalised Covid-19 patients.
An effective, convenient Covid-19 treatment could reach annual sales of over US$10 billion, said a recent Jefferies & Co estimate. Merck has a contract with the US government that implies a price of US$700 for a course of treatment with its antiviral molnupiravir.
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